Description

Remdesivir is an adenosine nucleotide prodrug that is metabolised intracellularly to the pharmacologically active nucleoside triphosphate metabolite (GS-443902). Remdesivir triphosphate acts as an ATP analog and competes for incorporation into RNA chains by the RNA-dependent RNA polymerase, resulting in delayed chain termination during replication of the viral RNA. It has a broad spectrum of activity against members of CoVs (e.g. SARS-CoV, MERS-CoV), the filoviruses (e.g. EBOV, MARV), and paramyxoviruses (e.g. respiratory syncytial virus [RSV], Nipah virus [NiV], and Hendra virus) in studies.