Description

Indications/Uses
Acute infections caused by susceptible strains of Pseudomonas aeruginosa eg,UTI, infections of the meninges & blood stream. Infections caused by H. influenzae specifically meningeal infections (intrathecal route only), E. coli specifically UTI, Aerobacter aerogenes & Klebsiella pneumoniae specifically bacteremia, when less potentially toxic drugs are ineffective or contraindicated.
Dosage/Direction for Use
IV Adult & childn 15,000-25,000 u/kg/day every 12 hr. Infant Up to 40,000 u/kg/day. Kidney impairment Reduce from 15,000 u/kg downward every 12 hr. Total daily dose: Not >25,000 u/kg/day. IM Adult & childn 25,000-30,000 u/kg/day divided at 4-6 hr intervals. Infant Up to 40,000 u/kg/day. Intrathecal Adult & childn >2 yr 50,000 u once daily for 3-4 days then 50,000 u once every other day for at least 2 wk after cultures of CSF are -ve & sugar content returned to normal. Childn <2 yr 20,000 u once daily for 3-4 days or 25,000 u once every other day. Continue 25,000 u once every other day for at least 2 wk after cultures of CSF are -ve & sugar content returned to normal.