Description

Indications/Uses
Treatment of HTN & heart failure. Prophylaxis to patients w/ asymptomatic left ventricular dysfunction to delay the onset of symptomatic heart failure & those w/ left ventricular dysfunction to reduce the incidence of coronary ischemic events, including MI.

Dosage/Direction for Use
HTN Initially 5 mg/day. Usually 10-40 mg/day as a single or 2 divided doses. Renal impairment CrCl ≤30 mL/min (serum creatinine ≥3 mg/dL) 2.5 mg once daily on the 1st dose. Then may titrate dose upward until BP is controlled. Max of 40 mg daily. Ped hypertensive patients 1 mth to 16 yr 0.08 mg/kg (up to 5 mg) once daily. Max: >0.58 mg/kg (or >40 mg). Heart failure Initially 2.5 mg/day. Maintenance: 20 mg/day as a single dose or in 2 divided doses. Recommended dosing range: 2.5-20 mg bid. Max daily dose: 40 mg in divided doses. Asymptomatic left ventricular dysfunction Initially, 2.5 mg bid. Titrate as tolerated to the targeted daily dose of 20 mg in divided doses. Renal impairment (serum creatinine >1.6 mg/dL) or hyponatremia (serum Na <130 mEq/L) Initially at 2.5 mg daily. May increase dose to 2.5 bid, then 5 mg bid & higher as needed, usually at intervals of 4 days or more. Max daily dose: 40 mg. Administration Should be taken with food: Take w/ food or immediately after meals. Contraindications Hypersensitivity. History of angioneurotic edema.