Hepabig is a sterile solution containing Hepatitis B immune globulin (HBIG) which is prepared by Cohn fractionation method from plasma of individuals with high titers of anti-HBs and whose plasma does not show serologic evidence of HBsAg.
Also, donor units found to be negative to anti-HIV 1/2 and anti-HCV are only used in the preparation of Hepabig.
