Description

Pharmacokinetics: Citicoline is a water-soluble compound with >80% bioavailability. Pharmacokinetic studies on healthy adults show oral doses of citicoline are rapidly absorbed, with <1% excreted in feces. Plasma levels peak in a biphasic manner, at 1 hr after ingestion followed by a 2nd larger peak at 24 hrs post-dosing. Citicoline is metabolized in the gut well and liver. The byproducts of exogenous citicoline formed by hydrolysis in the intestinal wall are choline and cytidine. Following absorption, choline and cytidine are dispersed throughout the body, enter systemic circulation for utilization in various biosynthetic pathways and cross the blood-brain barrier for resynthesis into citicoline in the brain. Indications/Uses Treatment of stupor caused by head trauma, cerebral surgery, acute stage of cerebral infarction and hemiplegia after cerebral apoplexy. Treatment of Parkinson's disease in combination with anticholinergics. Concomitant therapy with antiproteolytic agents for pancreatitis.