Description

Pharmacology: Ampholip contains the antifungal agent, amphotericin B, complexed with phospholipids. Amphotericin B is a macrocyclic, polyene, broad-spectrum antifungal antibiotic produced by Streptomyces nodosus. The lipophilic moiety of amphotericin B allows molecules of the drug to be complexed in a ribbon-like structure with the phospholipids.
Mechanism of Action: Amphotericin B, the active antifungal agent in Ampholip, may be fungistatic or fungicidal, depending on its concentration and on fungal susceptibility. Amphotericin B acts by binding to ergosterol in the fungal cell membrane causing subsequent membrane damage. As a result, cell contents leak from the fungal cell and ultimately, cell death occurs.